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Table 1 Characterization of Patient and Prior Treatments

From: Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis

Patient

Age (Years)

Sex

HPV type

Age at diagnosis (Years)

Number of RRP surgeries lifetime

Prior local treatments

Prior systemic treatments

Pulmonary RRP lesions

1

32

F

11

19

> 40

Cidofovir

I-3-C

No

2

36

M

6

28

35

Cidovofir, bevacizumab

I-3-C

No

3

50

F

11

5

> 250

Mitomycin

Diindolylmethane

Yes

4

63

M

11

19

> 50

Cidofovir, Cryotherapy

None

No

5

27

F

6

6

> 50

None

None

No

6

53

F

11

38

> 20

Cidofovir

None

Yes

7

55

M

6

53

11

Cidovofir, bevacizumab

None

No

8

55

F

6

51

16

None

None

No

9

56

M

11

54

> 20

Cidofovir

None

No

10

21

M

6

1

> 100

Cidovofir, bevacizumab

Interferon, Methotrexate

Yes

11

67

M

6

28

> 40

bevacizumab, PDT

I-3-C

Yes

12

26

M

11

2

> 100

Cidofovir, bevacizumab

Interferon, I-3-C

No

  1. Abbreviations: HPV human papillomavirus, RRP recurrent respiratory papillomatosis, PDT photodynamic therapy, I-3-C indole-3-carbinol