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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Fig. 1

Frequency and activation state of DC subsets in HLN and breast cancer SLN. Vertical columns represent the different DC subsets. On the left the two CD1a + migratory cDC subsets (LC and dDC), on the right the two LN resident DC subsets (LNRcDC and (pDC). In each dot plot data of HLN and metastasis negative (SLN-) and metastasis positive (SLN+) breast cancer SLN is compared. a Frequencies of DC subsets, expressed as percentage of total LN cells. b Expression levels of activation/maturation (CD40, CD83) and co-stimulatory (CD86) surface receptors on different DC subsets, expressed as percentage of positive cells within each subset. Bars represent mean +/− SEM. * p = 0.01 to 0.05; ** p = 0.001 to 0.01; ***p = 0.0001 to 0.001 and **** p < 0.0001 in a one way ANOVA or Kruskal-Wallis with post-hoc multiple comparison Tukey’s or Dunn’s test. Of note: mean primary tumor size in the SLN- group was 1.41 cm and 2.67 cm in the SLN+ group

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