Fig. 1From: Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph nodeFrequency and activation state of DC subsets in HLN and breast cancer SLN. Vertical columns represent the different DC subsets. On the left the two CD1a + migratory cDC subsets (LC and dDC), on the right the two LN resident DC subsets (LNRcDC and (pDC). In each dot plot data of HLN and metastasis negative (SLN-) and metastasis positive (SLN+) breast cancer SLN is compared. a Frequencies of DC subsets, expressed as percentage of total LN cells. b Expression levels of activation/maturation (CD40, CD83) and co-stimulatory (CD86) surface receptors on different DC subsets, expressed as percentage of positive cells within each subset. Bars represent mean +/− SEM. * p = 0.01 to 0.05; ** p = 0.001 to 0.01; ***p = 0.0001 to 0.001 and **** p < 0.0001 in a one way ANOVA or Kruskal-Wallis with post-hoc multiple comparison Tukey’s or Dunn’s test. Of note: mean primary tumor size in the SLN- group was 1.41 cm and 2.67 cm in the SLN+ groupBack to article page