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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: CD45RA+CCR7 CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab

Fig. 1

Nivolumab treatment does not result in changed numbers of peripheral immune cell populations, except eosinophils and T cells. Blood samples taken from patients at baseline, V1 and V2 were stained, ery-lysed and subsequently analyzed by multi-color FCM. Immune cell populations that were enumerated and markers used are listed in Additional file 1: Table S2, panel 1. Median numbers of immune cell populations of healthy controls are indicated by a dark grey, dotted line, and upper and lower quartile ranges are indicated by light grey dotted lines. Statistically significant differences between BOR groups were determined using Mann–Whitney U test. * p < 0.05; ** p < 0.01. BOR = best overall response, PR = partial response, SD = stable disease, PD = progressive disease, HC = healthy control

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