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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

Fig. 2

Tumor mutation profile and changes in copy number, mutation burden in pre- CCRT and post-CCRT biopsy samples. a, Heatmap of somatic mutations (including missense, nonsense, and splicing) detected in 29 study patients. Each patient had a paired column (1st: Pre-CCRT and 2nd: Post-CCRT). Samples were annotated for mutation quantity, immune or stromal score changes, and surgical pathology. Each bar portrayed in the bottom represents the proportion of each type of substitution. b, Copy number alteration was analyzed from pre- and post-samples. c, Tumor purity was calculated by whole-exome sequencing. d, Comparison of mutation burden and neoantigen frequency between pre-CCRT and post-CCRT samples (n = 29). Abbreviations: CCRT, concurrent chemoradiation therapy; pCR, pathologic complete response

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