Fig. 4
From: Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide
Antitumor activities of MEL and MEL-dKLA in vivo. (a) Tumor size, (b) tumor weight, (c) tumor size fold change, (d) and body weight were measured. Tumor-bearing mice were treated with each peptide every 3 days (for a total of three times) starting on day 5 after tumor inoculation. Tumor fold change was calculated based on the tumor size of the last day normalized to the initiation of tumor growth on day 5 (n = 5). (e) Immunofluorescence staining of endothelial cells in subcutaneously implanted LLC tumor paraffin sections. (f) Vessel density was quantified as integrated density per area (μm2) by Image J. Total magnification, 630×. Scale bar, 50 μm. (n = 6). All data are presented as means ± SEMs; *P < 0.05, **P < 0.01, ***P < 0.0001 versus the PBS group; #P < 0.05, ##P < 0.01, ###P < 0.0001 versus the dKLA group