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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide

Fig. 7

Antitumor effect of MEL-dKLA in an orthotopic model of lung cancer. (a) Representative images showing the lungs of wild mice (WT) and LLC tumor-inoculated mice treated with 175 nmol/kg of each peptide every 3 days. Drugs were administered 5 days after tumor injection into the left lung. Tumors are marked with black arrows. Size bar, 1 cm. (b) Representative H&E-stained histologic sections of the paraffin-embedded left lung. Magnification, × 1.5; size bar, 1 mm. Percentage of tumor area was calculated as tumor area per total area by Image J (left bottom panel). (c) Tumor size and (d) weight of left lung were measured at the end of the experiment on day 16. *P < 0.05, **P < 0.01 versus the PBS group; #P < 0.05, ##P < 0.01 versus the dKLA group; $$P < 0.01 versus the MEL group (n = 7 per group; WT n = 4)

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