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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Discovery of a novel natural killer cell line with distinct immunostimulatory and proliferative potential as an alternative platform for cancer immunotherapy

Fig. 4

Comparative analysis of the cytotoxicity and effector molecule secretion by NK-92 and NK101. a Indicated cell lines were co-cultured with NK101 (black bar) and NK-92 (white bar) at an effector-to-target ratio of 4:1 for 24 h. The percentages of apoptotic tumor cells were quantified by Annexin-V and fixable viability dye staining via flow cytometry. Percentage of specific lysis was calculated by the formula described in Online Additional file 2. *p < 0.05, **p < 0.01. b IFN-γ, TNF-α, perforin, and granzyme B concentrations in the co-culture supernatants were determined by ELISA. All data represent mean ± SD of 3 independent experiments. **p < 0.01

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