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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Temporal changes within the (bladder) tumor microenvironment that accompany the therapeutic effects of the immunocytokine NHS-IL12

Fig. 1

Antitumor effects of NHS-muIL12 on MB49luc bladder tumors. a NHS-muIL12 treatment (days 9, 12 and 15) and analyses (days 18, 21) schedule of mice bearing MB49luc bladder tumors. b Representative in vivo luciferase expression images taken immediately prior to euthanasia at days 6, 18, 21, and 32 for control Ig– (top row) and NHS-muIL12–treated mice (bottom row). c Individual bladder weights from control Ig–treated (circles, triangles) and NHS-muIL12–treated (squares, inverted triangles) mice at 72 and 144 h post–final NHS-muIL12 injection (days 18 and 21). Horizontal lines represent the average bladder weight; error bars represent mean ± SEM, Student’s t-test; *P < 0.05. Data are from a representative experiment that was repeated with similar results

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