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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Temporal changes within the (bladder) tumor microenvironment that accompany the therapeutic effects of the immunocytokine NHS-IL12

Fig. 3

Temporal-dependent phenotypic (72 and 144 h after the final NHS-muIL12 treatment) changes in myeloid/lymphoid cell profiles in the MB49luc bladder TME of control Ig– (black bars) and NHS-muIL12–treated (grey bars) mice. Panels a-c represent differences in absolute number of cells/mg bladder weight of (a) Ly6C+ MDSCs, (b) Ly6G+ MDSCs and (c) in the frequencies of M1 of CD11b+Gr1F4/80+ macrophages. (d) Total tumor TGF-β from control Ig– (black bars) and NHS-muIL12–treated (grey bars) mice at the 144-h time point (n = 5). e Frequencies of LAP+ CD3 cells. Error bars represent mean + SEM, Student’s t-test; *P < 0.05, unless otherwise indicated, n = 3. Data are from a representative experiment that was repeated twice with similar results

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