Skip to main content

Table 1 Baseline characteristics of 222 dogs with B-cell lymphoma treated with chemotherapy alone or with chemo-immunotherapy and stratified according to histotype

From: Opportunities and challenges of active immunotherapy in dogs with B-cell lymphoma: a 5-year experience in two veterinary oncology centers

Variable DLBCL (n = 148) MZL (n = 49) Follicular lymphoma (n = 25)
CH
(n = 47)
CH-IT
(n = 101)
P CH
(n = 24)
CH-IT
(n = 25)
P CH
(n = 6)
CH-IT
(n = 19)
P
Sex    0.522    0.484    0.175
 Male 25 48   12 15   4 6
 Female 22 53   12 10   2 13
Median age
(range) - years
9 (3–12) 7 (3–15) 0.677 8 (3–15) 7 (3–13) 0.110 10 (6–11) 9 (7–11) 0.774
Median weight
(range) - kg
31.9 (4.1–60.0) 28.8 (17–38) 0.787 20.7 (3.0–42.3) 26.0 (3.9–44.4) 0.556 29 (20–40) 20 (12–32) 0.171
PCV    0.063    0.189    0.430
 normal 46 89   20 24   5 18
 decreased 1 12   4 1   1 1
Platelet count    0.127    0.138    0.999
 normal 34 84   18 23   5 17
 decreased 13 17   6 2   1 2
LDH    0.689    0.567    0.999
 normal 23 53   15 13   4 11
 increased 24 48   9 12   2 8
Stage    0.310    0.999    0.999
 III-IV 15 41   4 4   2 8
 V 32 60   20 21   4 11
Peripheral blood infiltration    0.129    0.496    0.160
 no 17 50   6 4   5 8
 yes 30 51   18 21   1 11
Bone marrow infiltration    0.647    0.791    0.999
 no 20 47   5 6   3 9
 yes 27 54   19 19   3 10
Extranodal involvement    0.004*    0.680    0.562
 no 33 90   17 19   4 16
 yes 14 11   7 6   2 3
Substage    0.198    0.484    0.999
 a 27 69   14 17   5 14
 b 20 32   10 8   1 5
Steroids before referral    0.284    0.038*    0.540
 no 37 71   15 22   6 15
 yes 10 30   9 3   0 4
Rescue protocols    0.275    0.696    0.400
 untreated 1 8   1 1   1 1
 one RP administered 10 21   3 8   1 5
 more RP administered 5 23   4 5   0 2
Toxicity    0.167    0.667    0.211
 none/grades 1–2 39 85   21 23   3 15
 grades 3–4 5 15   3 2   2 3
 grade 5 3 1   0 0   1 1
  1. Abbreviations: DLBCL Diffuse large B-cell lymphoma, MZL marginal zone lymphoma, PCV Packed cell volume, LDH Lactate dehydrogenase, CH Chemotherapy, CH-IT Chemo-immunotherapy, RP Rescue protocol
  2. *Significant