Fig. 3
Frequency and Magnitude of T cell responses to 12MP by ELIspot assay ex vivo (a, c, e), and after IVS (b, d, f). The proportion and 90% confidence interval (CI) of patients with a response to 12MP pool are shown in panels A and B, for each cohort and subgroup. The magnitude of these responses (maximum number of spots per 1 × 105 CD8 T cells) is shown in (c) and (d), where each symbol represents the maximum response for a patient. If the values did not meet criteria for a response, they are shown as zero. Boxplots represent 25th to 75th percentiles, with tails showing the full range, except outliers. The number of peptides to which a response was detected is shown for each patient with a response ex vivo (e) and after IVS (f)