Fig. 3
From: Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer
Molecular signatures of neoepitope-specfic T-cell response. aThe signature of APPM, consisting of 31 APPM genes that are differentially expressed between patients with mutant-specific T-cell response (RES) and patients without (NonRES). b Stratificatioin of TCGA ovarian cancer patients into groups (tertiles) of high, middle and low expression of APPM signature, based on the median expression value of the signature in each patient. c Kaplan-Meier plot comparing TCGA ovarian cancer patients with high vs low expression level of APPM signature. d Comparision of tumor-infiltrating subtypes between TCGA ovarian cancer patients with high vs low expression level of APPM signature. e Expression of MYC in the TCGA cohort (in Z-score, left) comparing patients with high (purple) vs low (green) expression level of APPM signature, and in the Roswell Park (RP) cohort (in RPKM, right) comparing patients with (purple) vs without (green) mutant-specific T-cell response. f Correlation between the expression levels of APPM signature and MYC across the TCGA ovarian cancer patients (left) and Roswell Park (RP) patients (right)