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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma

Fig. 1

Increased IRF8 transcriptional levels are associated with improved disease-free survival in renal cell carcinoma. a Transcriptional analysis of IRF8 expression and macrophage infiltration was performed from TCGA data. Kaplan-Meier plot of survival by IRF8 transcriptional status (b). Patients with high levels of IRF8 expression had prolonged disease-free survival (P < 0.05 log-rank test). Disease-free survival of patients based on macrophage infiltration (as determined by deconvolution of TCGA data through CIBERSORT) (c) and combined macrophage and IRF8 expression (d). Patients with high levels of TAM infiltration and IRF8 had significantly better disease-free survival than patients with high levels of TAM and low expression of IRF8 (*P < 0.05 log-rank test). IRF8 and TAM scores were stratified based on a tertile method

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