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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma

Fig. 4

Overall survival is associated with IRF8 expression in metastatic tumors with high or low levels of macrophage infiltration. Kaplan-Meier plot of overall survival by macrophage infiltration, identified by CD68 expression, and IRF8 status within metastasis of renal cell carcinoma patients. Groups were stratified using median cut-off scores for macrophage infiltration (30% of evaluated tumor area). Metastatic patients with low levels of TAM and IRF8hi expression had a more than 10 year increase in median overall survival compared to patients with low TAM and IRF8lo phenotype (log-rank P < 0.001, HR = 0.2485, 95% C.I.: 0.1052–0.5869)

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