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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Fig. 1

IFNAR1 is down-regulated in CTLs of human colon cancer patients. a. IFNAR1 mRNA expression level data was extracted from TCGA Colon Cancer (COAD) dataset using GEPIA Gene Expression Profiling Interactive Analysis (GEPIA) Cancer Genomics Browser. The IFNAR1 expression level between human colon carcinoma tissues (n = 380) and adjacent normal tissues (n = 51) were compared. b. PBMCs were isolated from peripheral blood specimens of healthy donors (n = 10) and colon cancer patients (n = 20), stained with CD8- and IFNAR1-specific antibodies, and analyzed by flow cytometry. CD8+ T cells were gated for IFNAR1 receptor level (MFI). Shown are representative IFNAR1 MFI histograms of CD8+ T cells from one healthy donor (left panel) and one colon cancer patient (right panel). Staining with IgG isotype antibody was used as negative control. c. Quantification of CD8+ T cell IFNAR1 MFIs of healthy donors and cancer patients. Each dot represents IFNAR1 MFI of one donor or patient

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