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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Fig. 2

IFN-I suppresses tumor growth via an immune cell-dependent mechanism. a. WT (n = 10) and IFNAR1-KO mice (n = 5) were injected with MCA at the right flank (100 mg/mouse in peanut oil). Tumor growth was monitored over time starting at week 10. Two IFNAR1-KO mice developed tumor at 56 days after MCA injection and were sacrificed on day 86 due to tumor size limitation of the animal use protocol before the end of the experiment. Only 4 of the 10 WT mice developed tumor. Three of the WT and three of the IFNAR1-KO mice developed tumor around 10 weeks after MCA injection. One WT mouse developed tumor 90 days after MCA injection. Shown are tumor images from the three pairs of WT and IFNAR1-KO mice that developed tumor at about the same time (left panel). Tumor incidence is presented at the middle panel. Tumor growth kinetics in the three pairs of WT and IFNAR1-KO mice as shown in the right panel. * p < 0.05. ** p < 0.01. b. Murine colon carcinoma MC38 cells were injected to WT (n = 5) and IFNAR1-KO (n = 5) mice. Mice were monitored for tumor size starting at day 10 and sacrificed 18 days after tumor cell injection. Shown are tumor images (left panel) and tumor growth kinetics (right panel). ** p < 0.01. c. MC38 cells were injected s.c. to WT mice (n = 10) and mice with IFNAR1 deficiency only in T cells (IFNAR1-TKO, n = 5). Tumor formed in 3 of the 10 WT and 5 of the 5 IFNAR1-TKO mice. Shown are tumor image (left panel) and tumor growth incidence (middle panel). Tumor growth kinetics of the tumors as shown in the right panel. * p < 0.05

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