Fig. 1

Safety profiles of anti-PD-1 monotherapy, chemotherapy alone, or their combination in advanced nasopharyngeal carcinoma. a Bar plot depicts the incidence rates of grade 1–5 adverse events (divided into grade 1–2 and 3–5) in pembrolizumab, nivolumab, JS001, camrelizumab, chemotherapy, and camrelizumab plus chemotherapy. The rates of deaths and discontinuation rates due to adverse events are also presented. b Indirect comparisons of grade 1–5 and 3–5 adverse events in different regimens. The pooled odds ratios and 95% confidence intervals indicate the result of the top regimen versus the bottom regimen. Each cell contains the pooled odds ratios and 95% confidence intervals; significant results are indicated in red. c Bar plot depicts the toxicity spectra based on each of the specific adverse event. The upper section shows the incidence rates of immune-related adverse events and the lower section shows the incidence rate of other common class-specific adverse events. The incidence rates of pneumonitis in camrelizumab plus chemotherapy, and thyroiditis, proteinuria, hypoalbuminemia and vomit in camrelizumab were reported to be zero. The grade 1–2 adverse events of anemia and proteinuria were not reported for pembrolizumab