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Table 2 Summary of characteristics and clinical endpoints of the Singapore trial evaluating the combination of chemotherapy and adoptive T-cell therapy in NPC

From: Comparative safety and efficacy of anti-PD-1 monotherapy, chemotherapy alone, and their combination therapy in advanced nasopharyngeal carcinoma: findings from recent advances in landmark trials

Items

Singapore trial

Characteristics

 Phase

2

 Key eligibility criteria

Treatment-naïve recurrent/metastatic EBV-positive NPC

 Experimental regimen

Chemotherapy+EBV-CTLs: Gemcitabine 1000 mg/m2, and carboplatin (AUC 2) (days 1, 8 and 15) q4wks for 4 cycles, followed by EBV-CTL 1 × 108 cells/m2 on weeks 0, 2, 8, 16, 24, and 32

 Sample size

35

Clinical endpoints

 Median follow-up, months

29.9

 ORR (%)

71.5

 CR (%)

8.6

 PR (%)

62.9

 SD (%)

28.6

 PD (%)

0

 All grade AEs (%)

NR

 Grade 3–5 AEs (%)

NR

  1. Abbreviations: AUC area under the curve, CR complete response, EBV Epstein-Barr virus, EBV-CTLs EBV-specific cytotoxic T lymphocytes, NPC nasopharyngeal carcinoma, NR not reported, ORR objective response rate, q4wks every 4 weeks, PD progressive disease, PR partial response, SD stable disease
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