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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Pre-clinical investigation of the synergy effect of interleukin-12 gene-electro-transfer during partially irreversible electropermeabilization against melanoma

Fig. 1

Effect of pIRE treatment on tumor growth and survival. C57Bl/6 mice were intradermally injected with 0.5 × 106 B16F10-GFP tumor cells and treated with pIRE parameters: 10 square waved pulses of 1200 V, duration 100 μs, frequency 1 kHz. Tumor volume was followed up every day (d) post treatments with a digital caliper and GFP expression was monitored in vivo. a Macroscopic visualization of tumor size and GFP expression following pIRE treatment. Scale bar represents 5 mm. b Tumor growth representation of untreated tumors (Δ) and pIRE treated tumors (■). Values are means ± SEM. ***P < 0.001, (Two-way ANOVA analysis). c Kaplan-Meyer survival curve of untreated mice (gray line) and pIRE treated mice (black line). N = 10 mice per group. (*P < 0.05 (Log-rank (Mantel-Cox) Test)

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