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Table 1 Hematology analysis of male and female mice of both groups at D15 and D49

From: Pre-clinical investigation of the synergy effect of interleukin-12 gene-electro-transfer during partially irreversible electropermeabilization against melanoma

Female mice   D15 D49
Group 1 Group 2 Group 1 Group 2
Parameters Unity Control EGT Control EGT
White blood cells 10^3/μl 6.4 ± 1.7 2.9 ± 1.5 7.7 ± 2.1 6.3 ± 1.0
hemoglobin g/dl 13.0 ± 0.3 10.9 ± 3.5 13.8 ± 1.1 14.0 ± 1.3
Red blood cells 10^6/μl 5.5 ± 3.2 6.7 ± 2.1 8.4 ± 0.8 8.4 ± 0.7
Hematocrit % 26.6 ± 15.3 32.9 ± 11.6 40.6 ± 4.2 40.8 ± 3.9
Mean corpuscular volume fl 48.7 ± 0.2 48.5 ± 2.6 48.3 ± 0.3 48.4 ± 0.7
Platelets 10^3/μl 333 ± 180 536 ± 297 376 ± 6 373.8 ± 62.5
Mean corpuscular hemoglobin pg 28.3 ± 16.0 16.2 ± 1.5 16.4 ± 0.3 16.5 ± 0.3
Mean corpuscular hemoglobin concentration g/dl 58.4 ± 32.7 33.6 ± 4.0 34.0 ± 0.7 34.2 ± 0.1
Male mice   D15 D49
   Group 1 Group 2 Group 1 Group 2
Parameters Unity Control EGT Control EGT
White blood cells 10^3/μl 5.6 ± 2.3 8.0 ± 1.9 8.4 ± 0.1 7.5 ± 3.4
hemoglobin g/dl 13.0 ± 2.5 14.9 ± 1.0 13.9 ± 1.4 13.2 ± 0.7
Red blood cells 10^6/μl 7.6 ± 1.5 8.6 ± 0.6 8.3 ± 1.1 8.0 ± 0.3
Hematocrit % 36.8 ± 7.3 42.5 ± 1.9 40.9 ± 3.5 38.7 ± 1.3
Mean corpuscular volume fl 48.5 ± 0.1 49.6 ± 1.2 49.6 ± 2.6 48.3 ± 0.6
Platelets 10^3/μl 351 ± 6 345 ± 112 424 ± 62 368 ± 61
Mean corpuscular hemoglobin pg 17.0 ± 0.1 17.3 ± 0.4 16.8 ± 0.6 16.4 ± 0.3
Mean corpuscular hemoglobin concentration g/dl 35.2 ± 0.3 34.9 ± 1.1 34.0 ± 0.6 34.0 ± 1.1
  1. 2x25μg of pIL-12 were injected intradermally in the healthy skin of female and male C57Bl/6 mice. Electrotransfection was realized using HV-MV electrical parameters. Hematological parameters (white blood cells, hemoglobin, red blood cells, hematocrit, mean corpuscular volume, platelets, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration) were determined on 2 female and 2 male mice treated with control and 4 female and 3 male mice treated with GET sacrificed at D15 and on 2 female and 2 male mice treated with control and 4 female and 4 male mice treated with GET sacrificed at D49. Values represent mean ± SD