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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer

Fig. 7

MRI reveals improved tumor control and distinct response patterns following antigen-targeted prime/boost vaccination + anti-PD-1. a Axial T2-weighted images of a mouse over time demonstrating onset and growth of tumor lesions (yellow arrows) following IE9-mp1 tumor implantation (n = 5). b Schematic representation of study design for serial monitoring of response to combination therapy c MR-based tumor volume measurements of peritoneal lesions in mice from control and treatment groups at different times post vaccination (n = 3–5). d Axial T2-weighted images of a representative animal from all 4 experimental groups illustrating differences in tumor growth kinetics. Tumor lesions indicated with yellow arrows. e Temporal changes in the tumor volume of individual animals (n = 9) treated with MIS Vax + MRB-OVA + anti-PD-1 illustrating the heterogeneity in response pattern. Data presented as mean ± SEM

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