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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells

Fig. 3

NKG2D-BBz CAR-T cells had a potent cytotoxicity targeting glioblastoma CSCs. a The expression of CSC markers SOX2, nestin, and CD133 was detected by realtime PCR. The results are presented as the mean volume ± SD, * P < 0.05, ** P < 0.01, *** P < 0.001. b The co-expression of the glioblastoma stem cell marker NESTIN and NKG2DLs in GSC-3#, U251-CSC, U87-CSC cells was assessed by flow cytometry. Percentage of positive cells is detailed in the histograms. c Cytotoxicity of NTD, CD19-BBz and NKG2D-BBz T cells against cancer stem cells at different effector to target (E: T) ratios. The results are presented as the mean volume ± SD, *** P < 0.001

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