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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors

Fig. 4

Erlotinib-mediated tumor regression increases lung T cells. (a) Absolute number and (b) Fold change in number of parenchyma lung CD4 and CD8 T cells of tumor bearing CCSP-rtTA; TetO-EGFRL858R mice in the absence (−) and presence (+) of erlotinib for 2 weeks. Quantification of (C) Ki-67+ CD4 and CD8 T cells of tumor bearing CCSP-rtTA; TetO-EGFRL858R mice in the absence (−) and presence (+) of erlotinib for 2 weeks. (d) Immunofluorescent (IF) stain and (e) quantification of CD3 T cells (red) and Ki-67 positive cells (Cyan) in lungs of tumor bearing CCSP-rtTA; TetO-EGFRL858R mice in the absence (−) and presence (+) of erlotinib for 2 weeks. Nuclei were counterstained with Dapi (blue). Data are obtained from three independent experiments, (n = 4–6 mice per group). Data are shown as mean ± SD and * is P < 0.05 in a student’s t-test

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