Fig. 3

Cytokine expression in the TME. Granzyme B (a), Perforin (b), TNFa (c), IL2 (d), IL15 (e), IL12 (f), IL1b (g), CCL5 (h), IL10 (i). All the results are expressed as mean ± SEM (n = 4–6). a and b letters on the graphs indicate significantly different results when the superscript letters are different. The presence of two different letters in two groups indicate a statistical difference (p < 0.05) between them; the same letter in two different groups indicates the absence of a statistical difference between these two groups. The annotation “a,b” indicates no significant differences compared to a and b statistical groups