Fig. 2
From: Tumor mutational burden quantification from targeted gene panels: major advancements and challenges
TMB association with progression-free survival. Forest plot of hazard ratios (HR) comparing progression-free survival (PFS) between patients with high or low TMB, as indicated in the “Comparison” column. If not specified otherwise, TMB is reported as number of mutations per Mb. All patients were treated with immune checkpoint inhibitors (ICI). Bars represent the 95% confidence intervals. Size of the box is proportional to precision. Reference to the study and the analyzed cancer type are also reported together with the log-rank p-value. Q1-Q4: quartiles; VUS: variants of unknown significance. *: TMB quantified from blood; **: Cox proportional hazards model adjusted for age, gender, disease stage and prior therapy by ipilimumab