Fig. 1
From: Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
Graph showing the trend of the ANC and CRP for the first and second episode of neutropenia. 1D0 = Day 0 for first neutropenic episode, 2 D0 = Day 0 for second neutropenic episode. Corresponding days are measured based on days from the first neutropenic episode (1D0) and day of the second neutropenic episode (2D0). Note rise in CRP corresponds to fall in ANC in both instances. ANC improved with the use of filgrastim daily for 4 days at the first neutropenic episode and one dose of pegfilgrastim with the second neutropenic episode. Steroid taper for the first neutropenic episode was completed on day + 28 from neutropenia onset. ANC recovery in both episodes was observed 4 to 5 days from neutropenia onset