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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition

Fig. 3

Changes in CD-4 and CD-8 cell counts during immunotherapy. Serial CD4/CD8 T –cell counts were obtained from peripheral blood and are plotted on a Log10 scale showing changes during immunotherapy course. Post-C2 refers to the sample collected on the day of C3 day-1 before anti-PD-1 administration. Post C3 refers to the sample collected on the day of C4 day-1 before anti-PD-1 administration and also represents the sample obtained prior to hospitalization due to neutropenia. Post-C3, when compared to post-C2, was noted to have a 1.2 and 1.5 fold increase for CD8 and CD4 counts, respectively. Drop in CD4/CD8 cell counts at neutropenia was likely because the in-hospital sample collection was after treatment with immunosuppression. Post neutropenia sample collection was at clinic follow up after discharge

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