Fig. 1

Percentage of advanced non-small cell lung cancer (NSCLC) patients with an early response (partial and complete response according to the revised response evaluation criteria in solid tumors v1.1 [RECIST 1.1],) and durable response (stable disease, partial response and complete response according to RECIST 1.1 without progression in 6 months) to checkpoint inhibitors with and without circulating tumor cells (CTC) at T0 (a) and by increased or stable (ΔCTC) CTC counts when measured at 4 to 6 weeks of therapy (b). Early response rates were not significantly different (T0: OR = 0.67, p = 0.56; ΔCTC OR = 0.13, p = 0.08) but durable response rate was significantly lowered in patients with CTC (T0 OR = 0.28, p = 0.02; ΔCTC OR = 0.04, p = 0.01)