Fig. 3
From: Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment
Histology of the renal graft at the time of the kidney transplant biopsy and the explantation under nivolumab treatment (250 μm scale bar). Immunohistochemistry of the explanted kidney. a HE staining of the kidney biopsy shows diffuse cortical necrosis, hemorrhage and glomerular congestion. b HE staining of the renal explant shows moderate endothelialitis with focal fibrin deposition. c-i immunohistochemistry of the explanted kidney. c-e CD3+, CD4+ and CD8+ T-cells are present. f no CD20+ B-cells are present. g and h indicates the presence granzyme producing cells and proliferating cells (Ki-67) cells. Overall, there is influx of PD-1+ granzyme B-producing CD8+ T-cells in the vascular wall with endothelialitis. Magnification: 10x