Immune cell concentrations among the primary tumor microenvironment in colorectal cancer patients predicted by clinicopathologic characteristics and blood indexes

Table 3 Association between tumor markers and immune cells in the microenvironment

Variable	CD3+ T cells in the CT			CD3+ T cells in the IM			CD8+ T cells in the CT			CD8+ T cells in the IM			Immunoscore
Variable	Low	High	P	Low	High	P	Low	High	P	Low	High	P	Low	High	P
CEA	11.00 (0.39–12,257.00)	10.30 (0.56–3704.00)	0.593	12.21 (0.39–12,257.00)	8.53 (0.56–3704.00)	0.120	12.53 (0.56–3704.00)	7.89 (0.39–12,257.00)	0.064	10.54 (0.39–9064)	10.42 (0.56–12,257.00)	0.983	11.34 (0.39–12,257.00)	10.14 (0.56–3704.00)	0.295
CA 19–9	26.01 (0.60–18,707.00)	32.60 (0.60–20,000.00)	0.145	28.29 (0.60–18,707.00)	29.47 (0.60–20,000.00)	0.861	29.97 (0.60–20,000.00)	27.64 (0.60–18,707.00)	0.378	30.35 (0.60–5956.00)	27.64 (0.60–20,000.00)	0.993	28.43 (0.60–18,707.00)	30.33 (0.60–20,000.00)	0.544

CA 19–9 carbohydrate antigen 19–9, CEA carcinoembryonic antigen, CT core of the tumor, IM invasive margin