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Table 4 Association between inflammatory markers and immune cells in the microenvironment

From: Immune cell concentrations among the primary tumor microenvironment in colorectal cancer patients predicted by clinicopathologic characteristics and blood indexes

Variable CD3+ T cells in the CT CD3+ T cells in the IM CD8+ T cells in the CT CD8+ T cells in the IM Immunoscore
Low High P Low High P Low High P Low High P Low High P
LDH 171.70 (88.40–1957.80) 181.20 (1.97–2461.60) 0.508 177.85 (95.60–1957.80) 174.50 (1.97–2461.60) 0.615 171.05 (1.97–1856.80) 177.05 (88.40–2461.60) 0.427 174.15 (1.97–2461.60) 176.55 (88.40–1957.80) 0.430 174.50 (1.97–1957.80) 175.75 (88.40–2461.60) 0.777
ALB 40.15 (21.20–48.8) 40.25 (28.10–47.20) 0.926 39.75 (30.10–48.80) 40.30 (21.20–47.20) 0.558 40.35 (29.40–48.80) 39.65 (21.20–47.60) 0.402 40.25 (28.30–47.60) 40.10 (21.20–48.80) 0.923 40.45 (30.10–48.80) 39.65 (21.20–47.20) 0.228
CRP 4.80 (0.11–118.70) 4.82 (0.16–157.88) 0.759 4.36 (0.20–156.52) 5.11 (0.11–157.88) 0.582 3.99 (0.11–156.52) 5.12 (0.40–157.88) 0.163 4.40 (0.20–157.88) 4.84 (0.11–156.52) 0.931 4.00 (0.11–156.52) 5.53 (0.16–157.88) 0.164
Neutrophils 3.70 (0.50–14.80) 3.80 (0.90–20.80) 0.956 3.70 (0.50–10.80) 3.85 (0.80–20.80) 0.435 3.80 (0.50–20.80) 3.70 (0.80–14.80) 0.569 3.60 (0.50–11.50) 3.90 (0.90–20.80) 0.341 3.70 (0.50–11.50) 4.05 (0.90–20.80) 0.335
Lymphocytes 1.50 (0.40–13.70) 1.50 (0.20–6.30) 0.850 1.50 (0.40–13.70) 1.50 (0.20–11.40) 0.462 1.60 (0.50–6.30) 1.42 (0.20–13.70) 0.438 1.50 (0.40–13.70) 1.50 (0.20–11.40) 0.894 1.50 (0.40–13.70) 1.40 (0.20–11.40) 0.452
Monocytes 0.50 (0.20–1.60) 0.50 (0.10–0.96) 0.009 0.50 (0.10–1.60) 0.50 (0.20–1.40) 0.151 0.50 (0.20–1.05) 0.50 (0.10–1.60) 0.335 0.50 (0.20–1.00) 0.50 (0.10–1.60) 0.838 0.50 (0.20–1.60) 0.50 (0.10–1.40) 0.450
Platelets 238.00 (45.00–615.00) 244.50 (10.30–1181.00) 0.796 231.00 (45.00–1181.00) 249.00 (10.30–1060.00) 0.328 245.50 (79.00–1181.00) 230.50 (10.30–594.00) 0.310 235.00 (79.00–1060.00) 247.50 (10.30–1181.00) 0.169 241.50 (45.00–1181.00) 241.00 (10.30–594.00) 0.743
NLR 2.38 (0.21–16.75) 2.60 (0.43–62.50) 0.285 2.41 (0.21–16.75) 2.55 (0.43–62.50) 0.629 2.57 (0.43–16.00) 2.47 (0.21–62.50) 0.644 2.26 (0.21–16.75) 2.53 (0.43–62.50) 0.269 2.41 (0.21–16.75) 2.61 (0.43–62.50) 0.156
PLR 156.13 (7.58–541.70) 165.48 (7.92–984.17) 0.398 159.41 (7.58–984.17) 163.09 (7.92–581.11) 0.412 158.64 (25.56–984.17) 168.98 (7.58–530.00) 0.964 162.24 (7.58–530.00) 165.40 (7.92–984.17) 0.277 159.03 (7.58–984.17) 165.56 (7.92–581.11) 0.297
LMR 2.80 (0.90–22.83) 3.08 (0.40–12.60) 0.057 2.82 (0.90–22.83) 3.00 (0.40–9.50) 0.157 3.00 (1.00–12.60) 2.81 (0.40–22.83) 0.346 2.88 (0.80–22.83) 3.00 (0.40–10.00) 0.750 2.85 (0.90–22.83) 3.00 (0.40–10.00) 0.5853
  1. ALB albumin, CRP C-reactive protein, CT core of the tumor; IM invasive margin, LDH lactate dehydrogenase, LMR lymphocyte-to-monocyte ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio