Immune cell concentrations among the primary tumor microenvironment in colorectal cancer patients predicted by clinicopathologic characteristics and blood indexes

Guo, Guifang; Wang, Yixing; Zhou, Yixin; Quan, Qi; Zhang, Yijun; Wang, Haohua; Zhang, Bei; Xia, Liangping

doi:10.1186/s40425-019-0656-3

Table 4 Association between inflammatory markers and immune cells in the microenvironment

From: Immune cell concentrations among the primary tumor microenvironment in colorectal cancer patients predicted by clinicopathologic characteristics and blood indexes

Variable	CD3+ T cells in the CT			CD3+ T cells in the IM			CD8+ T cells in the CT			CD8+ T cells in the IM			Immunoscore
Variable	Low	High	P	Low	High	P	Low	High	P	Low	High	P	Low	High	P
LDH	171.70 (88.40–1957.80)	181.20 (1.97–2461.60)	0.508	177.85 (95.60–1957.80)	174.50 (1.97–2461.60)	0.615	171.05 (1.97–1856.80)	177.05 (88.40–2461.60)	0.427	174.15 (1.97–2461.60)	176.55 (88.40–1957.80)	0.430	174.50 (1.97–1957.80)	175.75 (88.40–2461.60)	0.777
ALB	40.15 (21.20–48.8)	40.25 (28.10–47.20)	0.926	39.75 (30.10–48.80)	40.30 (21.20–47.20)	0.558	40.35 (29.40–48.80)	39.65 (21.20–47.60)	0.402	40.25 (28.30–47.60)	40.10 (21.20–48.80)	0.923	40.45 (30.10–48.80)	39.65 (21.20–47.20)	0.228
CRP	4.80 (0.11–118.70)	4.82 (0.16–157.88)	0.759	4.36 (0.20–156.52)	5.11 (0.11–157.88)	0.582	3.99 (0.11–156.52)	5.12 (0.40–157.88)	0.163	4.40 (0.20–157.88)	4.84 (0.11–156.52)	0.931	4.00 (0.11–156.52)	5.53 (0.16–157.88)	0.164
Neutrophils	3.70 (0.50–14.80)	3.80 (0.90–20.80)	0.956	3.70 (0.50–10.80)	3.85 (0.80–20.80)	0.435	3.80 (0.50–20.80)	3.70 (0.80–14.80)	0.569	3.60 (0.50–11.50)	3.90 (0.90–20.80)	0.341	3.70 (0.50–11.50)	4.05 (0.90–20.80)	0.335
Lymphocytes	1.50 (0.40–13.70)	1.50 (0.20–6.30)	0.850	1.50 (0.40–13.70)	1.50 (0.20–11.40)	0.462	1.60 (0.50–6.30)	1.42 (0.20–13.70)	0.438	1.50 (0.40–13.70)	1.50 (0.20–11.40)	0.894	1.50 (0.40–13.70)	1.40 (0.20–11.40)	0.452
Monocytes	0.50 (0.20–1.60)	0.50 (0.10–0.96)	0.009	0.50 (0.10–1.60)	0.50 (0.20–1.40)	0.151	0.50 (0.20–1.05)	0.50 (0.10–1.60)	0.335	0.50 (0.20–1.00)	0.50 (0.10–1.60)	0.838	0.50 (0.20–1.60)	0.50 (0.10–1.40)	0.450
Platelets	238.00 (45.00–615.00)	244.50 (10.30–1181.00)	0.796	231.00 (45.00–1181.00)	249.00 (10.30–1060.00)	0.328	245.50 (79.00–1181.00)	230.50 (10.30–594.00)	0.310	235.00 (79.00–1060.00)	247.50 (10.30–1181.00)	0.169	241.50 (45.00–1181.00)	241.00 (10.30–594.00)	0.743
NLR	2.38 (0.21–16.75)	2.60 (0.43–62.50)	0.285	2.41 (0.21–16.75)	2.55 (0.43–62.50)	0.629	2.57 (0.43–16.00)	2.47 (0.21–62.50)	0.644	2.26 (0.21–16.75)	2.53 (0.43–62.50)	0.269	2.41 (0.21–16.75)	2.61 (0.43–62.50)	0.156
PLR	156.13 (7.58–541.70)	165.48 (7.92–984.17)	0.398	159.41 (7.58–984.17)	163.09 (7.92–581.11)	0.412	158.64 (25.56–984.17)	168.98 (7.58–530.00)	0.964	162.24 (7.58–530.00)	165.40 (7.92–984.17)	0.277	159.03 (7.58–984.17)	165.56 (7.92–581.11)	0.297
LMR	2.80 (0.90–22.83)	3.08 (0.40–12.60)	0.057	2.82 (0.90–22.83)	3.00 (0.40–9.50)	0.157	3.00 (1.00–12.60)	2.81 (0.40–22.83)	0.346	2.88 (0.80–22.83)	3.00 (0.40–10.00)	0.750	2.85 (0.90–22.83)	3.00 (0.40–10.00)	0.5853

ALB albumin, CRP C-reactive protein, CT core of the tumor; IM invasive margin, LDH lactate dehydrogenase, LMR lymphocyte-to-monocyte ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio

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