| |
Progression-free survival
|
Overall survival
|
|---|
|
HR (IC95%)
|
p-value
|
HR (IC95%)
|
p-value
|
|---|
|
EUA
|
1.6 (0.6–2.2)
|
0.645
|
2.2 (1.1–4.8)
|
0.038
|
|
PS 2
|
2.1 (1.1–4.1)
|
0.023
|
1.8 (0.7–4.4)
|
0.198
|
|
Hg rate (continuous)
|
0.8 (0.0–0.9)
|
0.005
|
0.8 (0.6–1.1)
|
0.174
|
|
Alb rate < 30 g/dl
|
1.1 (0.5–2.3)
|
0.908
|
0.5 (0.2–1.5)
|
0.216
|
|
Kras mutation
|
0.7 (0.4–1.2)
|
0.181
|
0.4 (0.0–0.9)
|
0.020
|
|
PDL1 ≥ 1%
|
1.6 (0.6–4.2)
|
0.295
|
3.0 (0.9–10.8)
|
0.085
|
|
Citrulline < 20 μM
|
3.8 (1.4–99.9)
|
0.008
|
2.4 (0.6–10)
|
0.222
|
|
Presence of Gemmatimonadaceae
|
2.9 (0.9–9.2)
|
0.073
|
16.4 (3.9–68.5)
|
< 0.001
|
- HR hazard ratio, EUA early use of antibiotics, PS Performance status, Hg hemoglobin, Alb albumin
