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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Tumor mutation burden and circulating tumor DNA in combined CTLA-4 and PD-1 antibody therapy in metastatic melanoma – results of a prospective biomarker study

Fig. 3

Impact of baseline patients’ and disease characteristics on overall survival since the beginning of combined immunotherapy. 1Log rank test / 2Log rank test for Trend. *significant. a Tumor mutation burden (TMB) > 23.1 Mut/Mb vs. TMB ≤ 23.1 Mut/Mb, p = 0.061. b ctDNA measured by tumor-specific variant copies/ml of plasma detectable vs. undetectable at first follow-up, p = 0.006*1. c ctDNA measured by tumor-specific variant copies/ml of plasma increasing vs. not increasing at first follow-up, p = 0.03*1. d Cell-free DNA decrease > 50% vs. stable vs. increase > 50%, p = 0.005*2. e Targeted treatment (TT) before start of combined immunotherapy vs. no TT before, p = 0.001*1. f Men vs. women, p = 0.005*1. g Liver metastasis baseline vs. no liver metastasis baseline, p=0.013*1. h LDH baseline normal vs. elevated, p = 0.001*1

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