Fig. 2
From: Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer
Numerous copy number amplifications characterize high TMB cancers. a CNA profiles of high TMB and low TMB group: heatmaps of aneuploidy score calculated via the intensities of the EPIC array (each tumor versus average normal). The scores of each arm are − 1 if lost, + 1 if gained, 0 if non-aneuploid, and “NA” otherwise; b Amplifications: q values of amplifications of all tumors of high−/low- TMB lung cancer tumors. Deletions: q values of deletions of all tumors of high−/low- TMB lung cancer tumors; c Confirmed number of genes that map to significantly amplified or deleted regions; d GO enrichment analysis showing the enriched pathways of amplified and deleted genes in high TMB lung cancers