Fig. 3From: Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancerThe relationship of HOX gene methylation status and TMB. a Top 6 differential methylation sites in hi-TMB comparing with low TMB group. cg16732616/DMRTA2, cg26521404/HOXA9, cg20326647/intergenic region, cg02443967/TLL2, cg09792881/DMRTA2 and cg16928066/EMX1 were significantly methylated in high TMB tumor tissues; b In hi-TMB lung cancer, CpGs that are hypomethylated are more likely to be found immediately upstream of the TSS and within the 1st exon, CpGs are hypermethylated (P value < 0.01, two-tailed Wilcoxon rank-sum test); c Venn diagram analysis revealed 437 genes associated with high TMB; d The heatmap of the all methylation probes related to 437 genes in high TMB, low TMB NSCLCs samples and the matched normal controlsBack to article page