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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Molecular and metabolic pathways mediating curative treatment of a non-Hodgkin B cell lymphoma by Sindbis viral vectors and anti-4-1BB monoclonal antibody

Fig. 5

SV and α4-1BB mAb stimulated chemotaxis, adhesion and enhanced T cell infirtration and activation in tumor. a Heat map of the expression pattern of SV + α4-1BB upregulated chemokine and chemokine receptor genes (Expression values are shown by Z-score.) Genes are hierarchically clustered by one minus Pearson correlation (day 7). b the percentage of CCR5+ cells was measured by flow cytometry (day 7). c, d The percentage of CD11a+ (c) and ICAM-1+ cells (d) was measured by flow cytometry. e the relative expression of CD11a (ltgal) and ICAM-1 was shown by heat map measured by RNA-Seq. Expression values are shown by Z score. f The percentage of OX40+ and ICOS+ T cells were measured by flow cytometry. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001. g The frequency of CD3 and CD8 T cells to total harvested cells from tumor was measured by flow cytometry. h CD8/Treg ratio of tumor infirtrated T cells. i The percentage of granzyme B+ CD8 T cells as indicated. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001

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