Skip to main content

Table 1 Patient characteristics

From: A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients

Demographic Covariates Categorical

n (%)

Tumor Type

 NSCLC all types

158 (71.5)

  Non-Squamous

96

  Squamous

42

  Unknown NSCLC type

20

 Melanoma

48 (21.7)

 RCC

14 (6.3)

 Mesothelioma

1 (0.5)

Treatment

 Nivolumab monotherapy (3 mg/kg Q2W)

221 (100)

Gender

 Male

138 (62.4)

 Female

83 (37.6)

Race

 Caucasian

195 (88.2)

 Other

5 (2.3)

 Unknown

21 (9.5)

WHO Performance Status

 

 0

63 (28.5)

 1

103 (46.6)

 2

4 (1.8)

 Unknown

51 (23.1)

Weight loss prior to start therapy (only in NSCLC)

 Yes

36 (16.3)

 No

81 (36.7)

 Unknown

104 (47.1)

Demographic and Laboratory Covariates Continuous

Median (IQR)

n (%)

 Age (yr)

65 (59–71)

221 (100)

 Body Weight (kg)

78.5 (70–88)

220 (99.5)

 Body Surface Area (m2)

1.95 (1.81–2.09)

205 (93)

 Tumor Burden 3D (cm3; only in NSCLC)

18.6 (66–98)

25 (11)

 Creatinine (μmol/L)

81 (66–98)

203 (92)

 CKD (mL/min)

81 (62–90)

203 (92)

 Total Protein (g/L)

73 (69–90)

163 (74)

 Albumin (g/L)

42 (42–45)

174 (79)

 LD (U/L)

215 (183–275)

196 (89)

 Leucocytes (109 cells/L)

7.7 (6.3–10.2)

203 (92)

  1. Baseline covariates of patients
  2. Abbreviations: n number of patients, IQR inter-quartile range, CKD CKD-EPI renal clearance, LD lactate dehydrogenase