Parameters | Units | Estimate | RSE (%) | Bootstrap estimate | Bootstrap 95% CI |
---|---|---|---|---|---|
Population parameters | |||||
 Clearance (CL) | L/day | 0.211 | 3.5 | 0.211 | 0.196 to 0.226 |
 Central volume of distribution (V1) | L | 3.46 | 5.8 | 3.46 | 3.09 to 3.83 |
 Peripheral volume of distribution (V2) | L | 3.46 | 5.8 | 3.46 | 3.09 to 3.84 |
 Inter-compartmental clearance (Q) | L/day | 0.48 | < 0.1 | 0.48 | 0.48 to 0.48 |
Covariate effects | |||||
 Female gender on CL | – | −0.17 | 29.1 | −0.17 | −0.27 to −0.06 |
 BSA effect on CL | – | 0.97 | 24.1 | 0.96 | 0.48 to 1.45 |
 Albumin effect on CL | – | −1.34 | 19.8 | −1.33 | −1.83 to − 0.86 |
Between-subject variability | |||||
 Clearance (CL) | CV% | 30.7 | 9 | 30.3 | 24.8 to 35.6 |
 Residual unexplained variability | |||||
 Proportional error | CV% | 31.8 | 8 | 31.8 | 29.1 to 34.2 |