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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity

Fig. 1

Suicide gene therapy effectively treats brainstem tumors without overt toxicity. (a) B16tk cells (right) or PBS (left) were stereotactically implanted into the brainstem of C57BL/6 mice that underwent T2 MRI imaging on Day 9. Inset H&E images at 4x. (b) Kaplan-Meier survival curve for B16tk tumors treated with two five-day courses of GCV and daily dexamethasone. (n = 10 mice/group) Figure is representative of two independent experiments. (c) Tumor volume assessment by T1 MRI imaging of treated and untreated mice. (n = 3 mice/group) Paired t-test of the difference in tumor volumes between Days 5 and 9 for each group. (d) Kaplan-Meier survival curve for B16tk tumors treated with 10Gy whole brain irradiation and GCV. (n = 9 mice/group) Figure is representative of one experiment

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