Fig. 1From: Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicitySuicide gene therapy effectively treats brainstem tumors without overt toxicity. (a) B16tk cells (right) or PBS (left) were stereotactically implanted into the brainstem of C57BL/6 mice that underwent T2 MRI imaging on Day 9. Inset H&E images at 4x. (b) Kaplan-Meier survival curve for B16tk tumors treated with two five-day courses of GCV and daily dexamethasone. (n = 10 mice/group) Figure is representative of two independent experiments. (c) Tumor volume assessment by T1 MRI imaging of treated and untreated mice. (n = 3 mice/group) Paired t-test of the difference in tumor volumes between Days 5 and 9 for each group. (d) Kaplan-Meier survival curve for B16tk tumors treated with 10Gy whole brain irradiation and GCV. (n = 9 mice/group) Figure is representative of one experimentBack to article page