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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity

Fig. 2

Suicide gene therapy generates brainstem inflammation. (a,b,c) Whole brain flow cytometry of mice bearing B16tk brainstem tumors treated with GCV or PBS from Days 4–8 and 10–14 post-tumor implantation. Leukocytes were gated as CD45Hi; Microglia were gated as CD45Mid, CD11b+; APCs were gated as CD45Hi and either CD11b+, CD11c + or MHCII+. * p ≤ 0.05 (n = 3–4 mice/group) (d) Representative histology from (c). H&E (20x, top) and anti-CD3 (red)/DAPI (blue) (40x, bottom), with quantitation in (e). * p < 0.05

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