Fig. 2From: Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicitySuicide gene therapy generates brainstem inflammation. (a,b,c) Whole brain flow cytometry of mice bearing B16tk brainstem tumors treated with GCV or PBS from Days 4–8 and 10–14 post-tumor implantation. Leukocytes were gated as CD45Hi; Microglia were gated as CD45Mid, CD11b+; APCs were gated as CD45Hi and either CD11b+, CD11c + or MHCII+. * p ≤ 0.05 (n = 3–4 mice/group) (d) Representative histology from (c). H&E (20x, top) and anti-CD3 (red)/DAPI (blue) (40x, bottom), with quantitation in (e). * p < 0.05Back to article page