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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity

Fig. 5

Transgenic T cells traffic to the brainstem and recruit endogenous immune cells. (a) Whole brain flow cytometry of mice treated as described in Fig. 4A. Analysis performed on Day 15 post-tumor implantation. * p ≤ 0.05 (n = 3 mice/group) (b) Representative histology from (a). H&E (20x, top) and anti-CD3 (red)/ DAPI (blue) (40x, bottom). (c) Splenocytes from mice treated with pmels and VSV-hgp100 and harvested in (a) and (b) were incubated for 6 h with vehicle, hgp10025–33, or SIINFEKL (ovalbumin immunogenic peptide), and underwent intracellular staining for cytokines. (n = 3 mice/group)

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