Fig. 3

CAF parameters by cell counts and survival of melanoma patients treated with anti-PD-1 therapy and control melanoma patients. Kaplan–Meier analysis of progression-free survival and overall survival of anti-PD-1 treated melanoma patients (a) and overall survival of control melanoma patients (b) according to CAF (Thy1, SMA, FAP) parameters by cell counts. Low and high statuses were objectively defined using thresholds determined by maximally selected rank statistics (see Methods). Abbreviations: CAF, cancer-associated fibroblast; HI, high; LO, low