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Table 2 Univariable and multivariable Cox regression analyses for progression-free survival of melanoma patients and CAF parameters by cell counts

From: Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma

Variable (LO/HI) Anti-PD-1 PFS
Univariable analysis Multivariablea analysis per variable Multivariablea analysis with Thy1, SMA, FAP
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Thy1+/total 2.18 (1.17–3.81) 0.016 2.34 (1.21–4.28) 0.013 1.90 (0.98–3.48) 0.058
SMA+/Thy1+ 0.55 (0.32–0.97) 0.038 0.55 (0.32–0.99) 0.048 0.71 (0.40–1.31) 0.26
FAP+/Thy1+ 1.77 (1.11–2.89) 0.017 2.08 (1.28–3.44) 0.0030 1.79 (1.06–3.04) 0.031
  1. Abbreviations: CAF cancer-associated fibroblast, CI confidence interval, HI high, HR hazard ratio, LO low, PFS progression-free survival
  2. aCox proportional hazards model included age, sex, mutation status, stage, treatment, and prior immune checkpoint blockade as covariates