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Table 2 Univariable and multivariable Cox regression analyses for progression-free survival of melanoma patients and CAF parameters by cell counts

From: Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma

Variable (LO/HI)

Anti-PD-1 PFS

Univariable analysis

Multivariablea analysis per variable

Multivariablea analysis with Thy1, SMA, FAP

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Thy1+/total

2.18 (1.17–3.81)

0.016

2.34 (1.21–4.28)

0.013

1.90 (0.98–3.48)

0.058

SMA+/Thy1+

0.55 (0.32–0.97)

0.038

0.55 (0.32–0.99)

0.048

0.71 (0.40–1.31)

0.26

FAP+/Thy1+

1.77 (1.11–2.89)

0.017

2.08 (1.28–3.44)

0.0030

1.79 (1.06–3.04)

0.031

  1. Abbreviations: CAF cancer-associated fibroblast, CI confidence interval, HI high, HR hazard ratio, LO low, PFS progression-free survival
  2. aCox proportional hazards model included age, sex, mutation status, stage, treatment, and prior immune checkpoint blockade as covariates
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