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Table 3 Univariable and multivariable Cox regression analyses for overall survival of melanoma patients and CAF parameters by cell counts

From: Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma

Variable (LO/HI)

Control OS

Anti-PD-1 OS

Univariable analysis

Univariable analysis

Multivariablea analysis per variable

Multivariablea analysis with Thy1, SMA, FAP

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Thy1+/total

1.65 (0.87–2.88)

0.12

4.66 (2.34–8.82)

< 0.0001

4.67 (2.19–9.53)

0.0001

3.02 (1.44–6.10)

0.0044

SMA+/Thy1+

0.45 (0.22–1.07)

0.070

0.34 (0.18–0.68)

0.0029

0.32 (0.16–0.67)

0.0027

0.62 (0.30–1.31)

0.20

FAP+/Thy1+

0.57 (0.37–0.88)

0.012

4.11 (2.05–9.14)

< 0.0001

4.64 (2.27–10.52)

< 0.0001

3.61 (1.65–8.56)

0.0011

  1. Abbreviations: CAF cancer-associated fibroblast, CI confidence interval, HI high, HR hazard ratio, LO low, OS overall survival
  2. aCox proportional hazards model included age, sex, mutation status, stage, treatment, and prior immune checkpoint blockade as covariates
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