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Table 3 Univariable and multivariable Cox regression analyses for overall survival of melanoma patients and CAF parameters by cell counts

From: Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma

Variable (LO/HI) Control OS Anti-PD-1 OS
Univariable analysis Univariable analysis Multivariablea analysis per variable Multivariablea analysis with Thy1, SMA, FAP
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Thy1+/total 1.65 (0.87–2.88) 0.12 4.66 (2.34–8.82) < 0.0001 4.67 (2.19–9.53) 0.0001 3.02 (1.44–6.10) 0.0044
SMA+/Thy1+ 0.45 (0.22–1.07) 0.070 0.34 (0.18–0.68) 0.0029 0.32 (0.16–0.67) 0.0027 0.62 (0.30–1.31) 0.20
FAP+/Thy1+ 0.57 (0.37–0.88) 0.012 4.11 (2.05–9.14) < 0.0001 4.64 (2.27–10.52) < 0.0001 3.61 (1.65–8.56) 0.0011
  1. Abbreviations: CAF cancer-associated fibroblast, CI confidence interval, HI high, HR hazard ratio, LO low, OS overall survival
  2. aCox proportional hazards model included age, sex, mutation status, stage, treatment, and prior immune checkpoint blockade as covariates