Fig. 1

Mean peripheral counts of CD4⁺ and CD8⁺ T cells and NK cells. Mean counts of CD4⁺ and CD8⁺ T cells and NK cells in PBMCs at each dose level are shown. Decreased CD4⁺ T-cell count due to IT1208 was more apparent in patients receiving 1.0 mg/kg rather than 0.1 mg/kg. CD8⁺ T-cell counts and NK-cell counts were also decreased immediately after IT1208 administration, but CD8⁺ T-cell counts subsequently increased until day 29 and surpassed the baseline level, which resulted in remarkably decreased CD4/8 ratios