Fig. 2

Accuracy outperformed correlation in assessing the performance of panel-based tumor mutational burden (TMB) estimation. a Changes in the correlation and accuracy when successively removing the cases with WES-based TMB ranking from the top 1–5% in each cancer type using the F1CDx panel. b The correlation between F1CDx- and WES-based TMB in different TMB subgroups (top 5%, top 5–20%, and bottom 80%) in 24 cancer types with R² ≥ 0.75. c The minimal number of genes needed to obtain a mean accuracy ≥ 90% varied among cancer types and correlated negatively with their TMB levels