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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1

Fig. 2

The effects of GALV-GP-R expression on human tumor cell lines in vitro and human tumor xenograft models in vivo. a Images of cell lines infected with Virus 12 (expresses GFP) top panel and (a) Images of cell lines infected with Virus 10 (expresses GFP and GALV-GP-R). b Images representing the cell killing effects of Virus 12 and (b) Virus 10 in a panel of tumor cells. c Individual tumor growth curves from mice treated with either vehicle, Virus 19 (expresses mGM-CSF) or Virus 16 (expresses mGM-CSF and GALV-GP-R) in the A549 lung cancer model and (d) in the MDA-MB-231 breast cancer model. The dose level of virus was in each case 5 × 103 pfu in 50 μl given 3x every other day. Statistical differences between groups were measured by one-way ANOVA at day 41 for the A549 model and at day 38 for the MDA-MB-231 model. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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