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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner

Fig. 6

A working model of the action of MICA α3-specific antibody alone and of MICA immune complex. A working model is proposed to illustrate 1) shed MICA blocks NKG2D mediated cellular interactions with surface-bound MICA (left panel); and 2) MICA α3-specific antibody can form immune complexes with sMICA leading to NKG2D and Fc-dependent NK cell activation (left panel); 3) MICA α3-specific antibody induces ADCC-mediated tumor cell killing and augments NKG2D signaling by stabilizing tumor surface MICA (right panel)

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