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Table 2 Comprehensive genomic profiling by FoundationOne™

From: Angiosarcoma patients treated with immune checkpoint inhibitors: a case series of seven patients from a single institution

Patient TMB Genomic Findings
4 15 muts/mb CDKN2A/B loss
CHEK2 R117G
DNMT3A R771
FANCD2 E118
MLL3 splice site 2533-1G > A
TP53 L145R, splice site 673-1G > A
5 12 muts/mb CRKL amplification
DNMT3A R635W – subclonal
MAPK1 amplification
SF3B1 K700E – subclonal
ZRSR2 splice site 121 + 2 T > G