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Table 1 Summary of immune-modulating drugs and their targets

From: Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges

Drug name Drug target Isotype Source
Ipilimumab CTLA-4 IgG1 Human
Nivolumab PD-1 IgG4 Human
Pembrolizumab PD-1 IgG4 Humanized
Atezolizumab PD-L1 IgG1 Humanized
Durvalumab PD-L1 IgG1 Human
Tremelimumab CTLA-4 IgG2 Human
Avelumab PD-L1 IgG1 Human
Utomilumab CD137 IgG2 Human
INCAGN01876 GITR IgG1 Humanized
INCAGN01949 CD134 IgG1 Human
Rovalpituzumab Tesirine DLL3 IgG1 Humanized
  1. CTLA-4 Cytotoxic T-Lymphocyte Antigen 4, PD-1 programmed cell death protein-1, PD-L1 programmed death ligand-1, GITR Glucocorticoid-induced TNF-receptor-related protein