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Table 1 Summary of immune-modulating drugs and their targets

From: Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges

Drug name

Drug target

Isotype

Source

Ipilimumab

CTLA-4

IgG1

Human

Nivolumab

PD-1

IgG4

Human

Pembrolizumab

PD-1

IgG4

Humanized

Atezolizumab

PD-L1

IgG1

Humanized

Durvalumab

PD-L1

IgG1

Human

Tremelimumab

CTLA-4

IgG2

Human

Avelumab

PD-L1

IgG1

Human

Utomilumab

CD137

IgG2

Human

INCAGN01876

GITR

IgG1

Humanized

INCAGN01949

CD134

IgG1

Human

Rovalpituzumab Tesirine

DLL3

IgG1

Humanized

  1. CTLA-4 Cytotoxic T-Lymphocyte Antigen 4, PD-1 programmed cell death protein-1, PD-L1 programmed death ligand-1, GITR Glucocorticoid-induced TNF-receptor-related protein